A modified insulin-like growth factor-1 analog researched for extended activity and its role in cellular growth and metabolic signalling.
IGF-1 LR3 is an analog of insulin-like growth factor-1 modified with an extended N-terminal sequence and an amino-acid substitution that reduces its binding to IGF-binding proteins. Research examines this greatly extended half-life and its activity at the IGF-1 receptor in cell-growth and metabolic model systems.
It is widely used in cell-culture research to study proliferation and differentiation. It is a research-only reagent.
Widely used in culture research to study cell growth and differentiation signalling.
Researched for reduced binding-protein affinity giving a longer half-life than native IGF-1.
Examined for downstream effects on protein synthesis pathways in model systems.
Investigated for influence on glucose and growth signalling in preclinical research.
Bring the vial (1 mg) and bacteriostatic water to room temperature.
Add bacteriostatic water slowly along the glass wall — the volume you add sets the concentration.
Swirl gently (do not shake) until fully clear, then refrigerate at 2–8 °C.
Studied together to model upstream GH release alongside downstream IGF-1 signalling.
Paired in research exploring the full growth-hormone-to-IGF axis in models.
Links open a PubMed search for the topic. They point to independent literature and are provided for orientation in a research context only.
It carries an extended N-terminal sequence and an amino-acid substitution that reduce binding-protein affinity, giving a markedly longer half-life studied in cell-culture and preclinical growth-signalling research.
It is commonly used in cell-culture systems to study proliferation, differentiation, and anabolic signalling through the IGF-1 receptor. It is a research-only reagent with no approved use.
Because IGF-1 sits downstream of growth hormone, researchers pair it with secretagogues and GHRH analogs to model the complete growth-hormone-to-IGF signalling axis.
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