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🔥 Metabolic & Fat Loss

MOTS-c

Mitochondrial ORF of the 12S rRNA type-c · Mitochondrial metabolic peptide

A mitochondrial-derived peptide studied for its role in metabolic regulation, insulin sensitivity, and cellular energy homeostasis in research models.

Type
Mitochondrial-derived peptide
Common sizes
10 mg · 40 mg
Research focus
Metabolic energy regulation
Often studied with
NAD+ · 5-Amino-1MQ
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What is MOTS-c?

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial genome that has been investigated for its influence on cellular metabolism. Research models explore its association with AMPK pathway activation, glucose handling, and the regulation of nuclear gene expression under metabolic stress conditions.

In laboratory settings, MOTS-c is frequently studied in the context of exercise physiology, insulin signaling, and age-related metabolic decline, positioning it as a subject of interest in mitochondrial biology research.

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Areas of research

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Glucose metabolism

Studied for its association with insulin sensitivity and glucose uptake in cellular research models.

⚡

AMPK signaling

Investigated for potential activation of AMPK, a key regulator of cellular energy balance.

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Exercise physiology

Researched in the context of exercise capacity and skeletal muscle metabolic adaptation.

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Mitochondrial function

Examined for its role in mitochondrial biogenesis and nuclear-mitochondrial signaling communication.

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In the lab: reconstitution

1

Bring the vial (10 mg · 40 mg) and bacteriostatic water to room temperature.

2

Add bacteriostatic water slowly along the glass wall — the volume you add sets the concentration.

3

Swirl gently (do not shake) until fully clear, then refrigerate at 2–8 °C.

Tip: The Peptide Calculator converts any vial size and water volume into units per syringe mark automatically.

Full storage & handling guide →

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Commonly researched combinations

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MOTS-c + NAD+

Studied together in research contexts exploring mitochondrial energy production and cellular metabolic pathways.

View stack →
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MOTS-c + 5-Amino-1MQ

Investigated in parallel for complementary interest in metabolic and adipose-related research models.

View stack →
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Selected research studies

MOTS-c — MOTS-c metabolismPubMed ↗
MOTS-c — MOTS-c AMPK insulinPubMed ↗
MOTS-c — mitochondrial derived peptide MOTS-cPubMed ↗

Links open a PubMed search for the topic. They point to independent literature and are provided for orientation in a research context only.

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FAQ

What is MOTS-c studied for?

MOTS-c is researched in the context of metabolic regulation, insulin sensitivity, and mitochondrial energy homeostasis. All investigation occurs within laboratory and preclinical research models, not clinical application.

How does MOTS-c relate to mitochondria?

It is a mitochondrial-derived peptide encoded within the mitochondrial genome. Research examines its potential signaling role between mitochondria and the nucleus during metabolic stress.

Is MOTS-c intended for human use?

No. MOTS-c is supplied strictly for laboratory research purposes. It is not approved for human or veterinary use and carries no medical indications.

Explore MOTS-c

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For laboratory research only. This guide is provided solely for scientific orientation. MOTS-c and all products are not intended for human or animal use, nor for the diagnosis, treatment or prevention of any disease. Nothing here is dosing guidance.
© Nephiz Labs · Peptide Guide: MOTS-c
Research-use information
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