A tripeptide fragment of alpha-MSH researched for its anti-inflammatory signalling in gut and immune model systems.
KPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone. Research explores its ability to modulate inflammatory pathways, including NF-kB signalling, without the pigmentary effects of the parent hormone. It appears to act at both intracellular and receptor-mediated levels in model systems.
Much of the literature centres on intestinal inflammation and immune-cell models. KPV is a research-only compound with no established clinical use.
Studied for downregulation of NF-kB and pro-inflammatory cytokine signalling in cell models.
Examined in colitis and gut-inflammation models for mucosal anti-inflammatory effects.
Researched for influence on macrophage and immune-cell activity in vitro.
Investigated for reducing inflammatory burden during experimental repair processes.
Bring the vial (10 mg) and bacteriostatic water to room temperature.
Add bacteriostatic water slowly along the glass wall — the volume you add sets the concentration.
Swirl gently (do not shake) until fully clear, then refrigerate at 2–8 °C.
Combined in gut research pairing anti-inflammatory signalling with repair mechanisms.
Studied together in immune-model research for complementary modulation pathways.
Links open a PubMed search for the topic. They point to independent literature and are provided for orientation in a research context only.
KPV is the C-terminal tripeptide sequence of alpha-MSH, researched for anti-inflammatory signalling while lacking the pigmentation effects associated with the full parent hormone.
Published research concentrates on intestinal inflammation models and immune-cell systems, where its modulation of NF-kB and cytokine pathways is examined.
Unlike full-length alpha-MSH, research indicates the KPV fragment does not carry the melanocyte-stimulating pigmentary activity, which is one reason it is studied separately.
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