ARA-290

Description

ARA-290, also known as cibinetide, is an investigational research peptide engineered from the tissue-protective region of erythropoietin. Unlike erythropoietin itself, ARA-290 is studied for tissue-protective signaling without stimulating the classical pathway responsible for red-blood-cell production.

Preclinical and clinical research has examined ARA-290 in models involving cellular injury, inflammatory signaling, peripheral nerve function, small-fiber neuropathy, neuropathic symptoms, and tissue-repair processes. Its research profile primarily focuses on activation of the innate repair receptor and the associated cellular protection and recovery pathways. ARA-290 remains investigational, and its safety and effectiveness for general use have not been established.

Research Applications

• Innate Repair Receptor Research
• Peripheral Nerve Models
• Inflammatory Pathway Studies
• Tissue-Protection Research

These applications reflect published experimental and clinical investigations involving nerve injury, small-fiber neuropathy, inflammation, cellular stress, and tissue protection.

Mechanism of Action

ARA-290 is studied as a selective ligand of the innate repair receptor, a heteroreceptor involving the erythropoietin receptor and the β-common receptor CD131. Research explores how activation of this signaling system may influence anti-inflammatory, anti-apoptotic, cellular-survival, tissue-protective, and repair-associated pathways without activating classical erythropoietic signaling.

Product Specifications

• Active ingredient: ARA-290 (Cibinetide; synthetic peptide, 11 amino acids)
• Sequence: pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser
• Molecular formula: C₅₁H₈₄N₁₆O₂₁
• Molecular weight: ~1257.3 g/mol
• CAS No.: 1208243-50-8
• Purity: ≥99 % (HPLC)
• Form: Lyophilized powder (acetate salt)

Size

• 10mg – 10mg per vial
• 100mg – 10 vials (10mg per vial)

Intended Use

This product is intended exclusively for laboratory and scientific research purposes. It is not intended for human consumption, medical use, diagnostic procedures, or veterinary applications.

Storage

Before Reconstitution

• Store in a cool, dry place.
• Protect from direct sunlight.
• Keep the vial tightly sealed.
• Follow any additional conditions stated on the product label or certificate of analysis.

After Reconstitution

• Store refrigerated at 2–8°C unless otherwise specified by the supplier.
• Avoid repeated freeze-thaw cycles.
• Protect from contamination by following proper laboratory handling procedures.
• Follow any peptide-specific stability requirements stated on the certificate of analysis.

Warnings

• For Research Use Only.
• Not for Human Consumption.
• ARA-290 is an investigational peptide.
• Keep out of reach of children.
• Do not use if the vial or seal is damaged.
• Handle using appropriate laboratory procedures.
• Avoid direct contact with the skin, eyes, and clothing.
• Verify product identity, purity, and formulation against the applicable certificate of analysis.
• Dispose of materials according to local laboratory regulations.

PRODUCT CLASSIFICATION: RESEARCH PRODUCT — NOT FOR HUMAN OR ANIMAL USE