A synthetic fragment related to Thymosin Beta-4 studied for cell migration, actin regulation, and tissue-repair mechanisms in preclinical research.
TB-500 corresponds to an active region of Thymosin Beta-4, a naturally occurring actin-sequestering protein. Research explores its role in regulating actin polymerisation, promoting endothelial and keratinocyte migration, and modulating inflammatory responses in injury models.
Preclinical studies span cardiac, dermal, and musculoskeletal tissue. It is used strictly as a research reagent and has no approved medical application.
Central to research on actin sequestration and cytoskeletal dynamics during cell movement.
Studied for cell migration and repair in preclinical musculoskeletal injury research.
Investigated in animal models for cardiomyocyte survival and vascular signalling after injury.
Examined for keratinocyte migration and reduced scarring in experimental wound models.
Bring the vial (5 mg · 10 mg) and bacteriostatic water to room temperature.
Add bacteriostatic water slowly along the glass wall — the volume you add sets the concentration.
Swirl gently (do not shake) until fully clear, then refrigerate at 2–8 °C.
Common research pairing combining actin-driven migration with angiogenic repair signalling.
Studied together in dermal-repair models for migration plus copper-mediated remodelling.
Links open a PubMed search for the topic. They point to independent literature and are provided for orientation in a research context only.
TB-500 is a synthetic fragment representing an active region of the full Thymosin Beta-4 protein, used in research to study actin-binding and cell-migration mechanisms in laboratory models.
Published preclinical work focuses on musculoskeletal repair, cardiac injury models, and dermal wound healing, where cell migration and actin dynamics are of interest.
No. It is a research-only compound with no approved human or veterinary therapeutic use and should be handled solely in laboratory settings.
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